Endocrine Abstracts

The follicle-stimulating hormone receptor knockout (FORKO) female mouse provides a useful model to examine the role that lack of estrogen plays in the development of obesity and hypertension in postmenopausal women. Estrogen increases circulating levels of atrial natriuretic peptide (ANP), a hormone with renal and cardiovascular effects. It has been shown that atrial natriuretic peptide (ANP) is a potent stimulator of fat cell lipolysis in addition of its well established effe...